Propionic acidemia and zinc deficiency presenting as necrolytic migratory erythema.
نویسندگان
چکیده
Necrolytic migratory erythema was first described in 1942 in a patient with pancreatic islet cell carcinoma. The disease can, however, have other etiologies including nutritional dermatoses. Here, we describe the clinicopathological picture of a 7-year-old female patient who presented with necrolytic migratory erythema which we believe is secondary to a rare combination of zinc deficiency and propionic acidemia.
منابع مشابه
Glucagonoma without cutaneous manifestations.
A 63 year old man presented with features of the glucagonoma syndrome, that is thromboembolic disease, weight loss, raised sedimentation rate, diabetes mellitus, hypoproteinaemia and reduced plasma amino acid levels, but without necrolytic migratory erythema. The plasma glucagon level was raised and the tumour was demonstrated by abdominal CT scan. Immunofluorescent studies of the resected tumo...
متن کاملZinc and Skin Disorders
The skin is the third most zinc (Zn)-abundant tissue in the body. The skin consists of the epidermis, dermis, and subcutaneous tissue, and each fraction is composed of various types of cells. Firstly, we review the physiological functions of Zn and Zn transporters in these cells. Several human disorders accompanied with skin manifestations are caused by mutations or dysregulation in Zn transpor...
متن کاملGlucagonoma and necrolytic migratory erythema.
blood tests were normal except for glucose: 145 mg/dL. Baseline plasma glucagon levels were 1200 pg/mL. Serum zinc was 97 mcg/dL. An abdominal CT scan showed a large mass involving the body and tail of the pancreas. A distal pancreatectomy with splenectomy was performed and no evidence of metastatic disease was observed. The skin rash cleared within a week after the operation and the patient re...
متن کاملNecrolytic migratory erythema associated with glucagonoma syndrome: a case report.
Necrolytic migratory erythema is a rare skin condition that consists of migrating areas of erythema with blisters that heal with hyperpigmentation. It usually occurs in patients with an alpha islet cell tumor of the pancreas-or glucagonoma-and when associated with glucose intolerance, anemia, hyperglucagonemia, and weight loss defines the glucagonoma syndrome. We describe a 52-year-old female p...
متن کاملGlucagonoma syndrome: a case report with focus on skin disorders
Glucagonoma syndrome is a rare paraneoplastic phenomenon. Necrolytic migratory erythema is often one of the first presenting symptoms. We report a case of a 55-year-old man with a 2-year history of recalcitrant eruption. Abdominal computer tomography was performed, which revealed a tumor in the tail of the pancreas. After pancreatectomy, his cutaneous lesions vanished in a few days. Skin sympto...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Saudi medical journal
دوره 25 5 شماره
صفحات -
تاریخ انتشار 2004